Wound healing
A wound is generally defined as a pathological state in which tissues are separated
from each other and/or destroyed. Wound healing is a complex and dynamic process
that involves a variety of repair mechanisms in the individual layers of the skin
as the body attempts to close the wound and restore the functions of the damaged
tissue as quickly as possible. When wounds fail to heal, a chronic open wound
without anatomical or functional integrity results.
For any ulcer to heal
there must first be a good blood supply to the area, which in the presence of
a warm, moist environment will lead to the formation of a highly vascular, ulcer
bed (‘granulation tissue’). This promotes healing by allowing epithelial
(skin) cells to migrate across it’s the wound surface, from the sides, inwards.
The larger the surface area of the wound, the longer it tends to take to heal.
The process will be delayed by the presence of necrotic tissue (slough), infection
or exudate.
Leg ulcers usually present as open wounds which frequently
become infected causing strong and unpleasant odours. Such ulcers can be difficult
to treat because the levels of active growth factors within the wound are reduced
due to an imbalance between proteolytic enzymes and their inhibitors in chronic
wound exudate. This occurs because of an over expression of matrix metalloproteinases
which causes an abnormal degradation of the extracellular matrix, as well as inhibiting
growth factors preventing the wound from healing normally.
How to order
Kerraboot is available on prescription and listed in the Drug Tarriff part IXA.
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more
Usage
Guidelines Full instructions on how to correctly
apply Kerraboot and how often it should be changed as well as a detailed application
protocol. ......read more
